摘要 |
A composition suitable for use as an implant material in human beings and animals to replace absent bone tissue. The material comprises a biocompatible, particulate ceramic material as a bone-replacing component and a biodegradable polymeric material. The ceramic material is a non-resorbable material, and the biodegradable polymeric material functions as a binder for said ceramic material, the composition being an intimate mixture of, by weight, 4-30% of said polymeric material, 15-30% of water and balance the ceramic material, and said intimate mixture having a highly-viscous kneadable consistency. The composition is made by intimately mixing a gelled mixture, prepared from the biodegradable polymeric material and water with the ceramic component, using a high-power, low-speed kneader at a temperature of no more than 60<o>C, and subjecting the mixture thus produced to an elevated pressure of at least 10 MPa at room temperature for at least about 5 minutes. |
申请人 |
BRINKS, GERRIT, JOHANNES;BRINKS, JAN, CORNELIS |
发明人 |
BRINKS, GERRIT, JOHANNES;BRINKS, JAN, CORNELIS |