PERCUTANEOUSLY ABSORBABLE PHARMACEUTICAL OF NIFEDIPINE FOR EXTERNAL USE

摘要

PURPOSE:To obtain a percutaneously absorbable pharmaceutical for external use capable of absorbing nifedipine with excellent absorbability, by blending a mixture of N-methyl-2-pyrrolidone with oleic acid as an absorption accelerator. CONSTITUTION:A percutaneously absorbable pharmaceutical for external use obtained by blending a mixture of N-methyl-2-pyrrolidone with oleic acid at 9:1-1:4, preferably 1:1 mixing ratio with nifedipine which is a principal ingredient at 10-100:1 weight ratio of the mixture to the nifedipine so as to provide 10-100mg content of the nifedipine therein. Administration is extremely readily carried out by using the above-mentioned pharmaceutical and effects are sustained with excellent compliance. Side effects in digestive organs are eliminated.