发明名称 |
N-aryl-azetidinones, their preparation process and their use as elastase inhibitors |
摘要 |
The invention relates to N-aryl-azetidinones, their preparation process and their use as active serine elastase inhibitors. The N-aryl-azetidinones are in accordance with formula: <IMAGE> (I) in which R1 and R2 can be a halogen atom or an organic radical, R3 represents a halogen atom or another good starting group and R4 represents H or an organic radical. The compounds with R3=Cl or OSO2CH3, R4=H and R1=R2=F or R1=F and R2=Br are irreversible and selective elastase inhibitors.
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申请公布号 |
US5030628(A) |
申请公布日期 |
1991.07.09 |
申请号 |
US19890452774 |
申请日期 |
1989.12.19 |
申请人 |
SCIENTIFIQUE |
发明人 |
JOYEAU, ROGER;KOBAITER, RANDA;WAKSELMAN, MICHEL;REBOUD, MICHELE |
分类号 |
A61K31/395;A61K31/397;A61P29/00;C07D205/08;C07F7/18;C07F9/568 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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