发明名称 |
Compounds exhibiting anti-parasitic activity and a method for their use |
摘要 |
Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged imidazolium or other heterocyclic ring, a linking group, a phenyl ring, and a polar functional group. The polar functional group is preferably a quanylhydrazone or a heterocyclic hydrazone. A method is also provided for treating the diseases associated with Trypanosoma parasites which comprises administering to infected animals or humans an effective amount of a compound of the present invention.
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申请公布号 |
US5204352(A) |
申请公布日期 |
1993.04.20 |
申请号 |
US19870102445 |
申请日期 |
1987.09.29 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY |
发明人 |
SUNDBERG, RICHARD J.;DAHLHAUSEN, DANIEL J.;MANIKUMAR, GOVINDARAJAN;MAVUNKEL, BABU J.;MUSALLAM, HIKMAT A.;BISWAS, ATANU;VARADARAJAN, SRINIVASAN |
分类号 |
C07D213/53;C07D233/54;C07D471/04;C07D513/04 |
主分类号 |
C07D213/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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