GENE ENCODING PROTEIN HAVING ASYMMETRIC HYDROLASE ACTIVITY ON 4-SUBSTITUTED-1,4-DIHYDROPYRIDINE DERIVATIVES AND EXPRESSION PRODUCT OF THE SAME

摘要

A DNA fragment for efficiently obtaining a protein having an asymmetric hydrolase activity on 4-substituted-1,4-dihydropyridine derivatives; a transformant; and a process for producing the enzyme. An isolated gene originating in Streptomyces viridosporus chromosome and encoding a protein having an asymmetric hydrolase activity on 4-substituted-1,4-dihydropyridine derivatives; a plasmid having this gene integrated thereinto; a transformant constructed by this plasmid; and a process for producing the enzyme with the transformant. A process for the enzymatic conversion of 4-substituted-1,4-dihydropyridine derivatives by using the enzyme.