Asymmetric bioreduction of a ketone substrate with yeast produces the corresponding (R)-alcohol of structure (I), a key intermediate in the synthesis of beta 3-agonist of structure (a).
申请公布号
WO9803672(A1)
申请公布日期
1998.01.29
申请号
WO1997US12615
申请日期
1997.07.18
申请人
MERCK & CO., INC.;CHARTRAIN, MICHEL, M.;CHUNG, JOHN, Y., L.;ROBERGE, CHRISTOPHER
发明人
CHARTRAIN, MICHEL, M.;CHUNG, JOHN, Y., L.;ROBERGE, CHRISTOPHER