alpha -lactalbumin gene constructs

摘要

The present invention utilizes genetic engineering techniques to prepare non-human transgenic mammals that express human alpha -lactalbumin in their milk at a concentration of 2 mg/ml or greater. The invention also includes methods of preparing human alpha -lactalbumin in, for example, mice and cows. Also taught are methods for preparing human alpha -lactalbumin in which from one to four of its natural phenylalanine residues have been substituted by another amino acid.