发明名称 |
Fibrin microbeads and uses thereof |
摘要 |
Fibrin microbeads are prepared containing extensively cross-linked fibrin (ogen) without using glutaraldehyde. The fibrin microbeads are preferably prepared by containing an aqueous solution containing fibrinogen, thrombin and Factor XIII with an oil heated to about 50-80° C. to form an emulsion and mixing the emulsion at 50-80° C. until fibrin microbeads containing extensively cross-linked fibrin (ogen) are obtained. The fibrin microbeads may have a diameter of about 50-200 microns and can contain a bioactive agent. The fibrin microbeads are used for binding cells such as when culturing or separating one cell type from another, or when transplanting cells or engineering tissue. |
申请公布号 |
AU9481598(A) |
申请公布日期 |
1999.04.12 |
申请号 |
AU19980094815 |
申请日期 |
1998.09.15 |
申请人 |
V.I. TECHNOLOGIES, INC.;HADASIT MEDICAL RESEARCH & DEVELOPMENT LTD. |
发明人 |
GERARD MARX;RAPHAEL GORODETSKY |
分类号 |
C12N9/48;A61F2/00;A61K9/127;A61K9/16;A61K9/22;A61K9/26;A61K9/50;A61K35/12;A61K35/30;A61K35/407;A61K38/17;A61K38/43;A61L24/00;A61L26/00;A61L27/00;A61L27/22;A61L27/38;C07K14/745;C07K14/75;C12N5/00;C12N5/071;C12N5/077;C12P21/00 |
主分类号 |
C12N9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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