FIBROBLAST GROWTH FACTOR RECEPTOR-5

摘要

The present invention relates to fibroblast growth factor receptor-5, a novel member of the fibroblast growth factor receptor family. The invention provides isolated nucleic acid molecules encoding human FGFR5 receptors. FGFR5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGFR5 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of FGFR5 receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, defects in wound healing, mucositis, defects in angiogenesis, ischemia, host defense dysfunction, endocrine dysfunction, disorders in immune function, and/or disorders in insulin secretion.