PIPERAZINYL ALKYL TRIAZOLE COMPOUNDS AS DOPAMINE ANTAGONISTS BEING USEFUL FOR TREATMENT OF PSYCHOMANCY DISEASE

摘要

PURPOSE: Piperazinyl alkyl triazole compounds having selectively inhibiting activity at dopamine receptors are provided, which compounds are dopamine antagonists, so that they can be useful for treatment of psychomancy disease. CONSTITUTION: The piperazinyl alkyl triazole compounds represented by formula (1) or pharmaceutically acceptable salts thereof are provided, wherein n is an integer of 3 or 4; R1 is optionally substituted phenyl or optionally substituted benzhydryl, in which the substituent is C1-C6 alkyl, C1-C6 alkoxy, hydroxy, C1-C6 hydroxyalkyl, aryl, heteroaryl, amino, C1-C6 alkylamino, C2-C6 alkenyl, carbonyl, C3-C9 cycloalkyl and C3-C9 hetero ring; and R2 and R3 are independently hydrogen, C1-C6 alkyl or C1-C6 alkylester. A method for preparing the piperazinyl alkyl triazole compounds of formula (1) comprises reacting azide compound of formula (2) with alkylester compound of formula (3) in solution through combinatorial synthesis, wherein the solvent is dimethylformamide or acetonitrile.