摘要 |
A process for the manufacture of alpha-Difluoromethylornithine, analogs and derivatives is described from ornithine hydrochloride or from N<SUP>delta</SUP>-phthaloyl ornithine hydrochloride, conversion to an alkyl ester, conversion to solid derivatives through the formation of Schiff bases, subsequent halomethylation using suitable bases and hydrolysis.
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