| 主权项 |
1. A compound having Formula I: wherein A is C1-C8 alkyl, phenyl, pyridyl, oxazolidyl, or pyrimidyl optionally substituted with one or more groups chosen from C1-C5 alkyl, C1-C4 alkoxy, or halo; and R1 and R2 are independently chosen from hydrogen, C1-C8 alkyl, C1-C8 alkenyl, C1-C8 alkynyl, C1-C8 haloalkyl, C5-C6 cycloalkyl, C5-C6 heterocycloalkyl, C1-C3 alkylaryl, aryl, C1-C3 alkylheteroaryl, or heteroaryl, any of which is optionally substituted with acetyl, C1-C5 alkyl, amino, —NR6R7, —C(O)NR6R7, C1-C4 alkoxy, C1-C4 alkylhydroxy, C5-C6 cycloalkyl, C5-C6 heterocycloalkyl, aryl, heteroaryl, carbonyl, halo, hydroxy, thiol, cyano, or nitro; or R1 and R2 are joined such that together they form an alkylene bridge comprising 2 atoms so that a 5-membered ring is formed with the —NC(O)N— moiety, in which case A is as defined above or hydrogen, and which 5-membered ring is optionally substituted with R1′, R2′, R1″, and R2″, which are independently, hydrogen, or are C1-C8 alkyl, C5-C6 cycloalkyl, C5-C6 heterocycloalkyl, C1-C3 alkylaryl, aryl, C1-C3 alkylheteroaryl, or heteroaryl any of which is optionally substituted with amino, aryl, C1-C4 alkoxy, halo, or hydroxy; or R1′and R1″ together or R2″ and R2′ together form a carbonyl; or R1′ and R2′ are null and R1″and R2″ together form a fused phenyl group; and R6 and R7 are independently H, C1-C4 alkyl, or are joined such that together they form an alkylene bridge comprising 4 or 5 atoms so that a 5 or 6-membered ring is formed with the nitrogen; or a pharmaceutically acceptable salt or hydrate thereof. |
