发明名称 |
Novel HMG-CoA reductase inhibitors |
摘要 |
Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula <IMAGE> and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof. Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.
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申请公布号 |
US4863957(A) |
申请公布日期 |
1989.09.05 |
申请号 |
US19870135805 |
申请日期 |
1987.12.21 |
申请人 |
RORER PHARMACEUTICAL CORPORATION |
发明人 |
NEUENSCHWANDER, KENT W.;REGAN, JOHN R.;KOSMIDER, BENEDICT J. |
分类号 |
A61K31/365;A61P3/06;A61P9/10;A61P43/00;C07C59/54;C07C59/56;C07C59/64;C07D309/30 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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