发明名称 |
Muramyl dipeptide derivatives. |
摘要 |
The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I <CHEM> wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly indicated for use as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises. It is obtained by deprotection of a corresponding compound having one or more hydroxy groups(s) in protected form.
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申请公布号 |
EP0406175(A2) |
申请公布日期 |
1991.01.02 |
申请号 |
EP19900810480 |
申请日期 |
1990.06.26 |
申请人 |
SANDOZ LTD.;SANDOZ-PATENT-GMBH;SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. |
发明人 |
DUKOR, PETER;LEFRANCIER, PIERRE;STUETZ, PETER;CHEDID, LOUIS |
分类号 |
A61K38/00;A61K39/39;A61P37/00;A61P37/04;A61P37/08;C07K1/06;C07K9/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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