| 摘要 |
<p>A process for preparing an optically active dihydrosphingosine derivative, comprising reducing a (2R,3R)-2-amino-3-hydroxyalkanoic acid derivative represented by formula (III): <CHEM> wherein R<3> represents a straight-chain alkyl group having 7 to 21 carbon atoms; and R<4> represents an amino group protecting group, (e.g., (2R,3R)-2-benzylamino-3-hydroxyoctadecanoic acid) with sodium tetrahydroborate in the presence of an acid. The process of the invention makes it feasible to produce an optically active dihydrosphingosine at high optical purity and provides a simple process that is safe and easy to industrialize.</p> |
