IN-VITRO METHOD FOR DETECTING AND DIAGNOSING ACUTE CORONARY SYNDROMES

摘要

The invention relates to an in-vitro method for detecting acute coronary syndromes, especially of the acute myocardial infarction, by determining and assessing the content of choline, choline and/or trimethyl ammonium derivatives, selected from the group which comprises phosphorylcholine, plasmalogens and lysoplasmenylcholine, and/or from the reaction products thereof, selected from the group which comprises 1-O-alk-1'-enyl-2-substituted glycerol and 1-O-alk-1'-enyl-2-substituted glycerol phosphate, in body fluids or body parts. The inventive method comprises the following steps: withdrawing a sample of a suitable body fluid or of a body part, determining the content of choline, choline and/or trimethyl ammonium derivatives, selected from the group which comprises phosphorylcholine, plasmalogens and lysoplasmenylcholine, and/or from the reaction products thereof, selected from the group which comprises 1-O-alk-1'-enyl-2-substituted glycerol and 1-O-alk-1'-enyl-2-substituted glycerol phosphate, using a suited determination method (nuclear magnetic resonance methods, biochemical, enzymatic, immunological, clinicochemical, chromatographic, mass spectrometric, electrochemical, photometric methods or other methods); and assessing the measured results while taking a limiting value into consideration in order to detect or diagnose acute coronary syndromes, especially of an acute myocardial infarction.