RNA TARGETED 2'-MODIFIED OLIGONUCLEOTIDES THAT ARE CONFORMATIONALLY PREORGANIZED
摘要
2'-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries.
申请公布号
WO0006590(A1)
申请公布日期
2000.02.10
申请号
WO1999US16541
申请日期
1999.07.21
申请人
ISIS PHARMACEUTICALS, INC.;MANOHARAN, MUTHIAH;MOHAN, VENKATRAMAN;BOSWELL, HERB
发明人
MANOHARAN, MUTHIAH;MOHAN, VENKATRAMAN;BOSWELL, HERB