发明名称 |
C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities |
摘要 |
The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
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申请公布号 |
US6156790(A) |
申请公布日期 |
2000.12.05 |
申请号 |
US19970001242 |
申请日期 |
1997.12.30 |
申请人 |
HAUSER, INC.;JOHNS HOPKINS UNIVERSITY |
发明人 |
POSNER, GARY H.;WOO, SOON HYUNG;PLOYPRADITH, POONSAKDI;PARKER, MICHAEL H.;SHAPIRO, THERESA A.;ZHENG, QUN Y.;MURRAY, CHRISTOPHER;DAUGHENBAUGH, RANDALL J. |
分类号 |
C07D493/20;C07D519/00;(IPC1-7):A61K31/335;C07D493/18 |
主分类号 |
C07D493/20 |
代理机构 |
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