发明名称 |
Altered recombinases for genome modification |
摘要 |
The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.
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申请公布号 |
US2002094516(A1) |
申请公布日期 |
2002.07.18 |
申请号 |
US20010788297 |
申请日期 |
2001.02.16 |
申请人 |
CALOS MICHELE P.;SCLIMENTI CHRISTOPHER R. |
发明人 |
CALOS MICHELE P.;SCLIMENTI CHRISTOPHER R. |
分类号 |
C12N15/09;C12N9/00;C12N9/90;C12N15/90;C12R1/01;(IPC1-7):C12Q1/00;C12N9/22 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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