THIENOPYRIMIDINE DERIVATIVE

摘要

A thienopyrimidine derivative represented by the formula (I) or a salt thereof: (I) wherein R¹ represents a hydrogen atom, an alkyl group or the like; R² represents a hydrogen atom, an alkyl or amino group, or the like; R³ represents an alkyl, alkenyl or alkylthio group or the like or a group Y-X-; or R² and R³ may together form a tetramethylene group; X represents a direct bond or a linking group such as CH₂, CH(OH), S, O and NH; Y represents a substituted or unsubstituted aromatic carbocyclic, aromatic heterocyclic, cycloalkyl or saturated heterocyclic group or the like; Z represents S or O; and n represents an integer of 1 to 4. The derivative or salt has an inhibitory effect on PDE9, and is therefore useful in the prevention or treatment of overactive bladder, frequent urination, incontinence, dysuria associated with prostatomegaly, urinary calculus, Alzheimer disease, chronic obstructive pulmonary disease, myocardial infarction, thrombosis, diabetes or the like.