NOVEL HUMAN ssDNA BINDING PROTEINS AND METHODS OF CANCER DIAGNOSIS

摘要

A method for detecting transformed cells or tumour cells, a method for diagnosing or prognosing cancer or for assessing a predisposition to cancer, and kits for use in the methods are disclosed. The methods particularly involve the detection of overexpression of an ssDNA binding protein (SSB) or polypeptide comprising the following amino acid sequence: FX<SUP>1</SUP>X<SUP>2</SUP>DX<SUP>3</SUP>KPGLKNLNX<SUP>4</SUP>X<SUP>5</SUP>FIVLEX<SUP>6</SUP>GRVTKTKDGHEVRX<SUP>7</SUP>CKVADKTGSIX<SUP>8</SUP>ISVWDX<SUP>9</SUP>X<SUP>10</SUP>GX<SUP>11</SUP>LIQPGDI IRLTX<SUP>12</SUP>GYASX<SUP>13</SUP>X<SUP>14</SUP>KGCLTLYTGRGGX<SUP>15</SUP>LQKIGEFCMVYSEVPNFSEPNPX<SUP>16</SUP>YX<SUP>17</SUP> X<SUP>18</SUP>QQ ( SEQ ID NO : 1).