Nanoparticle contrast agents for diagnostic imaging

摘要

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

主权项

1. A composition comprising, a nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety, wherein the nanoparticulate transition metal oxide is directly attached to the silane-functionalized non-targeting zwitterionic moiety without any intervening layer, and wherein the silane-functionalized non-targeting zwitterionic moiety comprises a reaction product of a precursor tri-alkoxy silane, wherein the precursor tri-alkoxy silane is selected from the group consisting of N-((2H-tetrazol-5-yl)methyl)-N,N-dimethyl-3-(trimethoxysilyl)propan-1-aminium, 2-(4-(3-(trimethoxysilyl)propylcarbamoyl)piperazin-1-yl)acetic acid, 3-(4-(3-(trimethoxysilyl)propylcarbamoyl)piperazin-1-yl)propanoic acid, and combinations thereof.