| 摘要 |
PROBLEM TO BE SOLVED: To treat chronic migraine.SOLUTION: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering from, e.g., a migraine headache. A combined paradigm of a fixed site/fixed dose and an optional pain-dependent variable dosage and injection site is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering from chronic migraine. The injection schedule requires a minimum dose of 155U using a fixed-site, fixed-dose injection regimen into 31-39 sites across 7 head/neck muscles, namely the frontalis, corrugator, procerus, occipitalis, temporalis, trapezius and cervical paraspinal muscles.SELECTED DRAWING: Figure 17 |
