| 摘要 |
PROBLEM TO BE SOLVED: To provide compositions for the treatment of peripheral vascular diseases including Raynaud's phenomenon or syndrome.SOLUTION: The present invention relates to a composition that contains cyclic nucleotide phosphodiesterase inhibitors, such as sildenafil and lodenafil, in combination with nitric oxide (NO) donors, such as L-arginine, and has an effect improving vascular blood flow in affected areas and thereby alleviating one or more symptoms associated with the disease, the composition being effective in the treatment of peripheral vascular disease, such as systemic sclerosis, CREST syndrome, systemic lupus erythematosus, rheumatoid disease, rheumatoid arthritis, and Sjogren's syndrome.SELECTED DRAWING: None |
