发明名称 |
Viral mutants that selectively replicate in targeted human cancer cells |
摘要 |
Oncolytic viruses are described that have favorable anti-cancer activity and that are produced by random mutagenesis and subsequent bio-selection on cancer cells wherein the viruses are preferably adenoviruses having at least one mutation in the i-leader sequence of the viral major late transcriptional unit.
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申请公布号 |
US2003021768(A1) |
申请公布日期 |
2003.01.30 |
申请号 |
US20020191922 |
申请日期 |
2002.07.09 |
申请人 |
SHEN YUQIAO;HERMISTON TERRY;FATTAEY ALI |
发明人 |
SHEN YUQIAO;HERMISTON TERRY;FATTAEY ALI |
分类号 |
A61K31/711;A61K35/76;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C07K14/075;C12N7/00;C12N7/01;C12N7/04;(IPC1-7):A61K48/00;C12N15/861 |
主分类号 |
A61K31/711 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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