发明名称 |
SUCCINIC ACID COMPOUNDS |
摘要 |
Succinic acid compounds of the formula: (see formula I) wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected from the group of a halogen atom, a lower alkyl group having 1 to 6 carbon atoms and a lower alkoxy group having 1 to 6 carbon atoms; B represents a bicyclic amino group which may have 1 or 2 unsaturated bonds, with the proviso that B bonds to the carbon atom of the carbonyl group at the nitrogen atom; R represents a hydrogen atom or combines each other to form a chemical bond; R1 represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms; when there is an asymmetric carbon atom, enantiomers thereof and racemic mixtures thereof; when there are geometrical isomers, each geometrical isomer, E-isomers thereof, Z-isomers thereof, cis-isomers thereof and traps-isomers thereof; and pharmaceutically acceptable salts thereof, enhance insulin secretion and possess a hypoglycemic activity, and are thus useful for the treatment of diabetes.
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申请公布号 |
CA2062877(A1) |
申请公布日期 |
1992.10.01 |
申请号 |
CA19922062877 |
申请日期 |
1992.03.12 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
SATO, FUMIYASU;TSUBAKI, ATSUSHI;HOKARI, HIROSHI;TANAKA, NOBUYUKI;SAITO, MASARU;AKAHANE, KENJI;KOBAYASHI, MICHIHIRO |
分类号 |
C07D209/08;C07D209/44;C07D217/06;C07D409/06;(IPC1-7):C07D209/02;C07D221/04;C07D401/06;C07D405/06;C07D215/08;A61K31/40;A61K31/435 |
主分类号 |
C07D209/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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