INHIBITOR DER BLUTPLÄTTCHEN-AGGREGATION

摘要

PCT No. PCT/GB91/01763 Sec. 371 Date Apr. 9, 1993 Sec. 102(e) Date Apr. 9, 1993 PCT Filed Oct. 10, 1991 PCT Pub. No. WO92/07005 PCT Pub. Date Apr. 30, 1992The inhibitor is protein derived leech tissue or leech secretions (for example, from Hirudo medicinalis), which is capable of binding to native collagen, in such a way that substantially no cleavage breakdown products of coilagen molecules occur on SDS-PAGE. The protein substantially inhibits collagen-induced platelet aggregation or adhesion, has a molecular weight of 60-70 kilodaltons in reduced form and has optimum activity at pH 8.0.