发明名称 |
Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
摘要 |
<p>The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid / glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained. <IMAGE></p> |
申请公布号 |
EP0896825(A1) |
申请公布日期 |
1999.02.17 |
申请号 |
EP19970810567 |
申请日期 |
1997.08.14 |
申请人 |
SULZER INNOTEC AG |
发明人 |
ATKINSON, BRENT A.;RANIERI, JOHN;BITTMANN, PEDRO;WHITNEY, MARSHA LYNN;BENEDICT, JAMES JOHN;CHICKERING, DONALD |
分类号 |
A61L27/00;A61F2/00;A61F2/02;A61F2/28;A61F2/30;A61K9/51;A61L27/54;A61P19/00;(IPC1-7):A61L27/00 |
主分类号 |
A61L27/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|