Modulation of gastrointestinal epithelium proliferation through the Wnt signaling pathway

摘要

These results indicate the efficacy of systemic expression of secreted Wnt antagonists as a general strategy for conditional inactivation of Wnt signaling in adult organisms, and illustrate a striking reliance on a single growth factor pathway for the maintenance of the architecture of the adult small intestine and colon. These results also indicate the potential utility of administration of Wnt pathway agonists for mucosal repair of the small intestine or colon.