发明名称 |
Phage antibodies to radiation-inducible neoantigens |
摘要 |
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor. |
申请公布号 |
US7306925(B2) |
申请公布日期 |
2007.12.11 |
申请号 |
US20030689006 |
申请日期 |
2003.10.20 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
HALLAHAN DENNIS E.;MERNAUGH RAYMOND |
分类号 |
C12Q1/68;A61K41/00;A61K51/12;C07K16/28;C07K16/30;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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