<p>Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an anti-PIV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete human or bovine PIV "background" genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV.</p>
申请公布号
EP2019141(A2)
申请公布日期
2009.01.28
申请号
EP20080164460
申请日期
2000.06.16
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
SCHMIDT, ALEXANDER C.;SKIADOPOULOS, MARIO H.;COLLINS, PETER L.;MURPHY, BRIAN R.;BAILLY, JANE E.;DURBIN, ANNA P.