Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
申请公布号
CA2687766(C)
申请公布日期
2016.06.28
申请号
CA20082687766
申请日期
2008.05.21
申请人
CHEMOCENTRYX, INC.
发明人
ZHANG, PENGLIE;PENNELL, ANDREW M. K.;WRIGHT, JOHN J. KIM;CHEN, WEI;LELETI, MANMOHAN R.;LI, YANDONG;LI, LIANFA;XU, YUAN;GLEASON, MARK M.;ZENG, YIBIN;GREENMAN, KEVIN LLOYD