método para preparar n-(4-cloro-3(triflúor metil)fenil)-n'-(4-(2-(n-(metil-d3)amino formil)-4-piridiloxi)fenil)uréia, intermediário, método para preparar 4-cloro-piridil-2-(n-(metil-d3))carboxamida, uso do intermediário e composto de ?-difenil uréia deuterada de p-tolueno sulfonato

摘要

Methods and processes for preparation and production of deuterated É-diphenylurea are disclosed. Especially, a kind of deuterated É-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N- d3 -methylcarbamoyl)-4-pridinylox y)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.