| 摘要 |
PROBLEM TO BE SOLVED: To provide a protective group of a 2'-hydroxy group of ribonucleoside, ribonucleotide, and a derivative thereof which are used in manufacturing oligo ribonucleic acid or the like.SOLUTION: A protective group that can be desorbed under a mild condition is stable under a reaction condition of a nucleic acid synthesis cycle, has small steric hindrance, and uses fluoride ions as a base, and is a protective group represented by the formula below. (O added with * denotes O of a 2'-hydroxy group of ribonucleoside, ribonucleotide, or a derivative thereof; both Rand Rare H, or denote a halogen atom, a Calkyl group, or a Chalo-substituted alkyl group; Rand Rdenote a hydrogen atom, a halogen atom, a Calkyl group, or a Chalo-substituted alkyl group; Rand Rdenote a halogen atom, a Chalo-substituted alkyl group, a cyano group, a nitro group or the like.)SELECTED DRAWING: None |
