| 摘要 |
<p>Cephalosporins of formula (I) and their acid-addn. salts and solvates are new. In formula (I), R1 is H or a protecting gp; R2 and R3 are each Me or Et; R4 is Me, Et, n-Pr, n-Bu, allyl, 2-butenyl, 3-butenyl, CH2CH2OH, CH2CH2CH2OH, CH2NMe2, pyridylmethyl, pyridylethyl, benzyl or phenethyl. (I) are antibacterial agents active against Gram- positive and -negative bacteria, e.g. with MIC values of 0.18-0.50 mcg/ml against cephalothinresistant E. coli and K. pneumoniae and 3.2-7.9 mcg/ml against Ps. aeruginosa.</p> |
