| 摘要 |
PURPOSE:To obtain the title compound having excellent economical efficiency and vasodepressor and smooth muscle relaxing action by reacting an optically active cyanodihydrodimethylepoxybenzopyran with oxopyrrolidine, dihydroxyoxopyridazine, etc. CONSTITUTION:An optically active 6-cyano-3,4-dihydro-2,2-dimethyl-3,4-epoxy-2 H-1-benzopyran is reacted with 2-oxopyrrolidine, 1,6-dihydro-3-hydroxy-6- oxopyridazine or 1,2-dihydro-2-oxopyridine in the presence of a base such as sodium hydroxide/dimethylsulfoxide to provide the objective compound expressed by the formula (R<1> and R<2> together are 2-oxopyrrolidinyl 1,6-dihydro-3-hydroxy-6- oxopyridazinyl or 1,2-dihydro-2-oxopyridyl). |
