摘要 |
<p>A compound of formula (I) wherein R1 is indolyl or benzofuranyl; R2 is hydrogen, lower alkylthio(lower)alkyl or a group of formula (1) in which R5 is hydrogen, lower alkoxy or halogen; R3 is hydrogen, quinolyl or phenyl which may have a suitable substituent selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio and halogen; R4 is hydrogen or optionally esterified carboxy; and X is S or NR6 in which R6 is hydrogen, lower alkyl or a group of formula (2) in which R7 is lower alkyl or lower alkoxy, and a pharmaceutically acceptable salt thereof, which possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases such as adult respiratory distress syndrome, cardiovascular ischemia, myocarditis, heart failure, and the like.</p> |