NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF

摘要

Amide derivatives represented by general formula (I), or their salts and medicinal compositions containing these derivatives and pharmaceutically acceptable carriers, wherein each symbol has the following meaning: A: heteroarylene; X: a bond, O, S, -NR<5>-, -NR<5>CO-, -NR<5>CONH-, -NR<5>SO2- or -NR<5>C(=NH)NH-; R<1>: H, optionally substituted lower aryl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted cycloalkyl; R<2a> and R<2b>: being the same or different from each other and each representing H or lower alkyl; R<3>: H or lower alkyl; R<4a> and R<4b>: being the same or different from each other and each representing H or OH, or R<4a> and R<4b> forming together =O or =N &tilde& O-lower alkyl; and R<5>: H or lower alkyl. These compounds are useful as remedies for diabetes having an insulin secretion accelerating effect together with an insulin sensitivity increasing effect.