发明名称 |
Inhibition of human telomerase by a g-quadruplex-interaction compound |
摘要 |
Certain non-nucleoside compounds that will selectively inhibit telomerase by targeting the nucleic add structures, such as G-quadruplexes, that may be associated with human telomeres or telomerase have been identified. Inhibition of human telomerase by two perylenetetracarboxylic acid diimides and a carbocyanine has been demonstrated. 1H-NMR studies have evidenced the stabilization of a G-quadruplex by the perylenetetracarboxylic acid diimide compounds and provided evidence that these and structurally related compounds inhibit the telomerase enzyme by a mechanism consistent with interaction with G-quadruplex structures.
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申请公布号 |
US6156763(A) |
申请公布日期 |
2000.12.05 |
申请号 |
US19990244675 |
申请日期 |
1999.02.04 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
KERWIN, SEAN M.;FEDOROFF, OLEG Y.;SALAZAR, MIGUEL;HURLEY, LAURENCE H. |
分类号 |
C07D277/64;C07D471/06;C12Q1/68;(IPC1-7):A61K31/44;C07D221/22 |
主分类号 |
C07D277/64 |
代理机构 |
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