P202 is a tumor suppressor

摘要

The present invention relates generally to the fields of cancer therapy and gene therapy. More particularly, the invention demonstrates methods for repressing or preventing transformation and proliferation of tumor cells. The method comprises contacting a cell with a p202 polypeptide in an amount effective to inhibit a transformed phenotype or cell proliferation. Inhibition of transformation may be indicated by a reduction in a transforming, tumorigenic or metastatic potential of a cell.