A dna molecule encoding a mutant prepro-neuropeptide y, a mutant signal peptide, and uses thereof

摘要

An isolated DNA sequence comprising a nucleotide sequence encoding a prepro-neuropeptide Y (preproNPY) where the leucine amino acid in position 7 of the signal peptide part of said preproNPY has been replaced by proline, said described polymorphism to the mutant form being associated with significant elevation of both total and LDL cholesterol levels; and a method of screening a subject to determine if said subject is a carrier of aforementioned mutant NPY gene.