MEDICINAL COMPOSITION FOR TRANSDERMAL ABSORPTION, MEDICINAL COMPOSITION STORING UNIT AND TRANSDERMAL ABSORPTION PREPARATION USING THE SAME

摘要

It is intended to provide a transdermal absorption preparation capable of sustaining the blood morphine concentration at the effective level over at least 48 hours, etc. This transdermal absorption preparation comprises a med icinal composition for transdermal absorption in which an active ingredient selected from among morphine and salts thereof is blended in such an amount as corresponding to the saturation solubility or more with an active ingredi ent-holding vehicle having fluidity at a temperature around the human skin s urface temperature and at least a portion of the active ingredient is held a s crystals, characterized in that, in the case where a preparation obtained from the above-described medicinal composition for transdermal absorption is applied to the uninjured back of a white rabbit having been shaven with ele ctrical clippers for 72 hours, the available dose of the active ingredient p er single dose of the preparation is from 10 mg to 400 mg in terms of morphi ne base, and the plasma concentrations of the active ingredient 24 hours and 48 hours after the application of the preparation under the above-described conditions are each at least 40 ng/mL in terms of morphine base, and so on.