发明名称 Methods for reducing the formation of by-products in the production of recombinant polypeptides
摘要 A method for reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the medium in a method for producing a polypeptide containing a serine residue by culturing transformed cells, and a method for producing a polypeptide containing a serine residue by culturing transformed cells, characterized by reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the medium.
申请公布号 US7547529(B1) 申请公布日期 2009.06.16
申请号 US20010030452 申请日期 2001.05.10
申请人 ASUBIO PHARMA CO., LTD. 发明人 YABUTA MASAYUKI;SAWANO TOSHIHIRO;MASUDA YUMIKO;OHSUYE KAZUHIRO
分类号 C12P21/02;C07K14/58;C12N15/16 主分类号 C12P21/02
代理机构 代理人
主权项
地址