Artificial blood vessel and method of manufacturing thereof

摘要

An artificial tissue capable of carrying necessary nutrients for maintaining activities of cells and tissues, and method of manufacturing artificial blood vessel. A plurality of forms of blood vessels are extracted from an image of living tissue and made into blood vessel form image. Each of the blood vessel forms of the blood vessel form image is adjusted and a blood vessel formation pattern is formed. A blood vessel cell culturing pattern of forming is formed, in a cell culturing layer. The blood vessel cell culturing pattern includes: a cell adhesion portion having adhesive properties with blood vessel cell and formed to the blood vessel formation pattern; and a cell adhesion-inhibiting portion having cell adhesion-inhibiting properties for inhibiting adhesion with a blood vessel cell and formed in an area other than the cell adhesion portion. A blood vessel cell is adhered to the cell adhesion portion, and cultured into tissue.

主权项

1. A blood vessel cell culturing pattern system comprising:
a) a base material; b) a cell culturing layer formed on the base material and having a pattern comprising a cell adhesion region and cell adhesion-inhibiting region; and c) at least one blood vessel cell adhered to the cell adhesion region; wherein the pattern of the cell culturing layer is a two-dimensional blood vessel pattern; wherein at least a portion of the cell adhesion region has a width greater than 100 μm, and within the cell adhesion regions having a width greater than 100 μm there is formed an auxiliary pattern of fine cell adhesion-inhibiting areas having a width of 0.5 to 10 μm.