Substituted imidazo[1,2-a]imidazo[4′,5′:4,5]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections

摘要

The present invention relates to compounds of formula (I) or salts, racemates, isomers and/or prodrugs thereof useful in the treatment of viral infections, in particular respiratory syncytial viral (RSV) infections. The present invention also relates to processes for preparing the compounds and intermediates used in their preparation.;

主权项

1. A compound of formula (I) wherein X1 is CR3; R3 is H; R4 is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, heterocyclyl or aryl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl and aryl is optionally substituted with one or more substituents selected from the group consisting of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 5-membered heterocyclyl, 6-membered heterocyclyl, aryl, halo, C1-6alkylhalo, C1-6alkylhydroxy, C1-6alkoxy, C1-6alkoxyhalo, oxo, acyl, carboxylate, cyano, nitro, amino, amido, aminoacyl, thiol, C1-6alkylthio, thioxo, sulfate, sulfonate, sulfonyl, sulfonyl and sulfonamido; R5 is R6, C(═O)R6, C(═S)R6 or S(O)2R6; R6 is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, heterocyclyl, aryl, N(R″)2, (NR″)q(R′″)qC3-8cycloalkyl, (NR″)q(R′″)qheterocyclyl or (NR″)q(R′″)qaryl, wherein (i) each R″ is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, heterocyclyl or aryl, (ii) each R′″ is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, heterocyclyl or aryl, and (iii) each q is independently 0 or 1, and further wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl and aryl is optionally substituted with one or more substituents selected from the group consisting of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 5-membered heterocyclyl, 6-membered heterocyclyl, aryl, halo, C1-6alkyl halo, hydroxy, C1-6alkylhydroxy, C1-6alkoxy, C1-6alkoxyhalo, oxo, acyl, carboxy, cyano, nitro, amino, amido, aminoacyl, thiol, C1-6alkylthio, thioxo, sulfate, sulfonate, sulfinyl, sulfonyl and sulfonamide; and each R7 is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, halo, C1-6alkylhalo, hydroxy, C1-6alkylhydroxy, C1-6alkoxy, C1-6alkoxyhalo, C(O)H, C(O)C1-6alkyl, C(O)2H, C(O)2C1-6alkyl, cyano, nitro, NH2, NH(C1-6alkyl), N(C1-6alkyl)2, NHC(O)H, NHC(O)C1-6alkyl, NHC(O)2C1-6alkyl, NHS(O)2C1-6alkyl, C(O)NH2, C(O)NH(C1-6alkyl), C(O)N(C1-6alkyl)2, SH, C1-6alkylthio, S(O)3H, S(O)3C1-6alkyl, S(O)H, S(O)C1-6alkyl, S(O)2H, S(O)2C1-6alkyl, S(O)2NH2, S(O)2NHC1-6alkyl, S(O)2N(C1-6alkyl)2, C3-6cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is optionally and independently substituted with one or more substituents selected from the group consisting of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 5-membered heterocyclyl, 6-membered heterocyclyl, aryl, halo, C1-6alkyl halo, hydroxy, C1-6alkylhydroxy, C1-6alkoxy, C1-6alkoxyhalo, oxo, acyl, carboxy, cyano, nitro, amino, amido, aminoacyl, thiol, C1-6alkylthio, thioxo, sulfate, sulfonate, sulfinyl, sulfonyl and sulfonamide;or pharmaceutically acceptable salts, racemates, stereoisomers and/or tautomers thereof.