发明名称 |
Azaadamantane formate ester and process for preparing azaadamantane derivatives |
摘要 |
A compound, (4s)-1-azaadamantane-4yl formate ester, is described. In addition, a process is described for preparing (4s)-1-azaadamantane-4yl formate ester, aminothiadiazole-phenyl phosphate salt, bromothiadizole-phenyl or (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]-decane dihydrogen citrate. Furthermore, a process is described, comprising step of hydrolyzing (4s)-1-azaadamantane-4yl formate ester to form (4s)-1-azaadamantan-4-ol HBr salt. |
申请公布号 |
US9359356(B2) |
申请公布日期 |
2016.06.07 |
申请号 |
US201514622657 |
申请日期 |
2015.02.13 |
申请人 |
AbbVie Inc. |
发明人 |
Kruger Albert Wayne;Chen Shuang;Cullen Steven Cramer;Napier James Joseph |
分类号 |
C07D221/22;C07D471/18;C07D285/12;C07D285/135;C07C249/02 |
主分类号 |
C07D221/22 |
代理机构 |
|
代理人 |
Chen Portia |
主权项 |
1. A process for preparing a compound, or salt of a compound, or solvate of a compound, of Formula (I) the process comprising step of: contacting (E)-N-benzylidene-1-(cyclohex-3-en-1-yl)methanamine with an aldehyde, or with an acetal, or with a hemiacetal, in presence of formic acid and a reaction medium. |
地址 |
North Chicago IL US |