Ring-fused compound

摘要

The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below.;
[in the formula,
R1 is -Q1-A1 and the like; is a double bond or a single bond; when is a double bond, W1 is a nitrogen atom or a group represented by the general formula: ═C(Ra)—, and W2 is a nitrogen atom or a group represented by the general formula: ═C(Rb)—; when is a single bond, W1 is a group represented by the general formula: —C(Raa)(Rab)— or a group represented by the general formula: —(C═O)—, and W2 is a group represented by the general formula: —C(Rba)(Rbb)—, a group represented by the general formula: —(C═O)— or a group represented by the general formula: —N(Rbc)—; W3, W4 and W5 are each independently a nitrogen atom or a methine group and the like that may have a substituent; X is a single bond, an oxygen atom and the like; Y is a single bond or (CRYiRYi′)n; and Z is a hydroxyl group or COOR2 and the like.

主权项

1. A compound represented by
Formula (I): [in the formula, R1 represents a group represented by the general formula: -Q1-A1; Q1 represents a methylene group; A1 represents a phenyl group, which may be substituted with one to three substituents selected from the described later (herein any two substituents adjacent to each other on the phenyl group may join together to form a lower alkylenedioxy group); represents a double bond or a single bond; when is a double bond, W1 represents a nitrogen atom or a group represented by the general formula: ═C(Ra)—, and W2 represents a nitrogen atom or a group represented by the general formula: ═C(Rb)—; when is a single bond, W1 represents a group represented by the general formula: —C(Raa)(Rab)— or a group represented by the general formula: —(C═O)—, and W2 represents a group represented by the general formula: —C(Rba)(Rbb)—, a group represented by the general formula: —(C═O)— or a group represented by the general formula: —N(Rbc)—; Ra and Rb represent each independently a hydrogen atom, a substituent selected from the described later or a group represented by the general formula: -Q2-A2; Raa and Rab represent each independently a hydrogen atom, a substituent selected from the described later or a group represented by the general formula: -Q2-A2, or Raa and Rab may join together to form a lower alkylene group (herein 1 to 2 or more methylene groups constituting the lower alkylene group each independently may be substituted with an oxygen atom, a carbonyl group, a vinylene group or a group represented by the general formula: —N(Rc)— for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a hydroxyl group, a lower alkyl group or a halogen atom); Rba and Rbb represent each independently a hydrogen atom, a halogen atom, an amino group, a lower alkyl-amino group, a di-lower alkyl-amino group, a hydroxy-lower alkyl-amino group, a lower alkyl-sulfonylamino group, a lower alkoxy-carbonylamino group, a substituent selected from the or a group represented by the general formula: -Q2-A2, or Rba and Rbb may join together to form a lower alkylene group (herein 1 to 2 or more methylene groups constituting the lower alkylene group each independently may be substituted with an oxygen atom, a carbonyl group, a vinylene group or a group represented by the general formula: —N(Rc)— for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a hydroxyl group, a lower alkyl group or a halogen atom); Rbc represents a group selected from the group consisting of a hydrogen atom, a lower alkyl group, a cycloalkyl group, a halo-lower alkyl group, a lower alkoxy-carbonyl group, a carbamoyl group, a mono-lower alkyl-carbamoyl group, a di-lower alkyl-carbamoyl group and a lower alkanoyl group or a group represented by the general formula: -Q2-A2; Q2 represents a single bond, a lower alkylene group or a lower alkenylene group (herein 1 or 2, or more methylene groups constituting the lower alkylene group each independently may be substituted with an oxygen atom, a nitrogen atom or a carbonyl group for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a halogen atom, a cyano group, a hydroxyl group or a lower alkyl group); A2 represents a cycloalkyl group, an aliphatic heterocyclic group, an aryl group or a heteroaryl group, which may be substituted with one to three substituents selected from the (herein any two substituents adjacent to each other on the aryl group or the heteroaryl group may join together to form a lower alkylenedioxy group); W3 represents a nitrogen atom, and W4 and W5 represent each independently a methine group that may have a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group, a cycloalkyl group, a halo-lower alkyl group, a lower alkoxy group and a halo lower alkoxy group; X represents a single bond; Y is a single bond; Z represents a 5-tetrazolyl group, a 5-oxo-1,2,4-oxadiazolyl group, a 2-oxo-1,3,4-oxadiazolyl group, a 5-imino-4,5-dihydro-1,3,4-oxadiazolyl group, a 2-thioxo-1,3,4-oxadiazolyl group or a 5-oxo-1,2,4-thiadiazolyl group; wherein, the , the and the are defined as described below: : a halogen atom, a hydroxyl group, a nitro group, a cyano group, a formyl group, an amino group, a carboxyl group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, a hydroxy lower alkyl group, a lower alkoxy lower alkyl group, a lower alkoxycarbonyl group, a lower alkanoyl group, a lower alkylthio group, a lower alkylsulfonyl group, a lower alkylamino group, a di-lower alkylamino group, a carbamoyl group, a mono-lower alkyl carbamoyl group, a di-lower alkyl carbamoyl group, a lower alkanoylamino group, a lower alkylsulfonylamino group, a lower alkoxycarbonylamino group, an aralkyl group, an aryloxy group, a heteroaryloxy group, and a lower alkenyl group, : a halogen atom, a hydroxyl group, a nitro group, a cyano group, a formyl group, an amino group, a carboxyl group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, a hydroxy lower alkyl group, a lower alkoxy lower alkyl group, a lower alkoxycarbonyl group, a lower alkanoyl group, a lower alkylthio group, a lower alkylsulfonyl group, a lower alkylamino group, a di-lower alkylamino group, a carbamoyl group, a mono-lower alkyl carbamoyl group, a di-lower alkyl carbamoyl group, a lower alkanoylamino group, a lower alkylsulfonylamino group, and a lower alkoxycarbonylamino group, : a hydroxyl group, a cyano group, a formyl group, a carboxyl group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, a hydroxy lower alkyl group, a lower alkoxy lower alkyl group, lower alkoxycarbonyl group, a lower alkanoyl group, a carbamoyl group, a mono-lower alkyl carbamoyl group, and a di-lower alkyl carbamoyl group]; or a pharmaceutically acceptable salt or ester of the compound.