发明名称 Methanethione compounds having antiviral activity
摘要 A compound of formula (I) is useful as an antiviral agent, in particular for the treatment of influenza. A method for preparing the compound of formula (I) and a composition including the compound of formula (I) are described.
申请公布号 US9359310(B2) 申请公布日期 2016.06.07
申请号 US201314401545 申请日期 2013.05.17
申请人 VIRONOVA INFLUENZA AB 发明人 Homman Mohammed;Kingi Ngarita;Bergman Jan;Berg Robert
分类号 C07D295/16;C07D261/18;C07D249/10;C07D249/06 主分类号 C07D295/16
代理机构 Young & Thompson 代理人 Young & Thompson
主权项 1. A compound of formula (I) wherein the ring A is 6-membered aryl; n is an integer of from 0 to 3; m is an integer of from 0 to 2; p is an integer of from 0 to 3; each R1 is independently selected from the group consisting of C1-C6 alkyl; C1-C6 alkoxy; OH; halogen; and R5R6N; R2 is selected from H and C1-C6 alkyl; each R3 is independently selected from C1-C6 alkyl; each R4 is independently selected from NO2; halogen; C1-C6 alkyl and C1-C6 alkoxy; R5 and R6 are independently selected from H and C1-C6 alkyl; wherein any alkyl is optionally substituted with one or several halogen atoms; and the ring of formula (III) is a ring of formula (IIIa), (IIIb), (IIIc), (IIId), or (IIIe): wherein in formula (IIIa), X is NH or O, and Y is N or CH, in formula (IIIb), X is N or CH, and Y is NH or O, in formula (IIIc), X is N, and Y is N or CH, in formula (IIId), X is N or CH, and Y is N or CH, and in formula (IIIe), X is N or CH, and Y is N or CH, or a pharmaceutically acceptable salt thereof.
地址 Stockholm SE