发明名称 USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME
摘要 The present invention describes the use of at least one compound of formula I or II or pharmaceutically acceptable salts thereof, for preparing a pharmaceutical composition that acts by inhibiting the phosphorylase uridine enzyme. Specifically, the present invention comprises the use of the said compounds for preparing a pharmaceutical composition that acts by inhibiting the human phosphorylase uridine enzyme, which can be optionally used in combination with at least one antineoplastic, wherein said inhibition increases the effectiveness of antineoplastic and decreases the side effects caused by the administration of antineoplastics.
申请公布号 EP3042657(A1) 申请公布日期 2016.07.13
申请号 EP20140842693 申请日期 2014.09.02
申请人 UNIÃO BRASILEIRA DE EDUCAÇAO E ASSISTÊNCIA- MANTENEDORA DA PUCRS 发明人 BASSO, LUIZ AUGUSTO;MACHADO, PABLO;RENCK, DAIANA;SANTOS, DIÓGENES SANTIAGO
分类号 A61K31/4412;A61K31/505;A61P35/00 主分类号 A61K31/4412
代理机构 代理人
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