| 摘要 |
<p>(A) 4-Glycopyranosyloxy-2-methyl -2-buten-1-al derivs. of formula (IVa) and (Va) are new: R4 = CH2OAc or COOMe; Ac = acetyl. (B) Prodn. of retinyl glycosides of formula (I) is effected by (a) reacting an acylated glycoside deriv. of formula (II) with a 4-hydroxy-2-methyl-2 -buten-1-al acetal of formula (III); (b) treating the prod. (IV) with an acid, (c) reacting the resulting aldehdye (V) with a beta-ionylidene -ethyl-triphenyl phosphonium salt of formula (VI) under Wittig conditions; and (d) removing the acyl gps. from the prod.: Z= a linear or branched glycoside gp. comprising 1-20 glycoxide units; Z'=Z in which all OH gps. are replaced by OCOR1; R1 = 1-10C alkyl or aralkyl, R2 and R3 = 1-10C alkyl or 7-10C aralkyl, or R2+R3 = ethylene or propylene opt. substd. by 1-4C alkyl; Y = a leaving gp.; X = a monovalent anion. (C) The use of cpds. (IV) and (V) for prodn. of medicaments is also new.</p> |
